Quiz › question 7 of 12 · Pharmacology

Why does dolutegravir raise serum creatinine without reducing true GFR?

A It is nephrotoxic at standard doses B It inhibits the tubular transporter OCT2 C It causes rhabdomyolysis D It increases creatinine production in muscle
Correct. Dolutegravir (like bictegravir, cobicistat and rilpivirine) inhibits tubular secretion of creatinine via OCT2/MATE1. Creatinine rises early, then plateaus, with no true change in glomerular filtration. A cystatin C-based eGFR avoids this.
Tivicay SmPC §4.4
← Previous Next question →