Quiz › question 1 of 12 · First-line ART

A 28-year-old man starts ART. HBsAg positive, HLA-B*57:01 negative, HIV RNA 90,000 copies/mL, CrCl 95 mL/min. Which regimen is appropriate?

A Dolutegravir/lamivudine (Dovato) B Bictegravir/emtricitabine/tenofovir alafenamide (Biktarvy) C Dolutegravir/abacavir/lamivudine (Triumeq) D Doravirine + lamivudine (two-drug)
Correct. Chronic hepatitis B needs tenofovir plus emtricitabine or lamivudine. Dolutegravir/lamivudine is explicitly not suitable for people who need tenofovir for hepatitis B, and abacavir/lamivudine does not treat HBV adequately — lamivudine alone selects HBV resistance.
BHIVA ART 2025 §5.10Dovato SmPC §4.4
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