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Capsid Capsid inhibitors

Mechanism of action

Lenacapavir binds the interface between capsid protein subunits, disrupting capsid-mediated nuclear import, assembly and capsid formation — it acts at several stages of the life cycle.

Genetic barrier to resistance

Reserved for multiclass resistance.

Class effects to know

  • Injection-site nodules and reactions
HIV-1 replication cycle and antiretroviral targets Seven steps from attachment to maturation, each labelled with the antiretroviral class that blocks it. CD4⁺ T cell Nucleus — host DNA provirus HIV virion new infectious virion Attachment & fusion gp120 binds CD4 then CCR5/CXCR4 Capsid transport & uncoating capsid docks at the nuclear pore Reverse transcription RNA → double-stranded DNA Integration integrase inserts provirus Transcription & translation host machinery makes viral RNA/protein Assembly & budding Gag/Gag-Pol at the membrane Maturation protease cleaves Gag-Pol Entry Capsid NRTI NNRTI INSTI Capsid PI

This class acts at the step labelled Capsid (uncoating).

Drugs in this class

Lenacapavir (LEN) SmPC not downloaded