:root {
  --bg: #f5f7fa;
  --surface: #ffffff;
  --surface-2: #eef2f7;
  --ink: #17212f;
  --ink-2: #4a5668;
  --line: #d9e0ea;
  --brand: #1d4e89;
  --brand-2: #2f6fb6;
  --accent: #0f8b8d;
  --ok: #1f7a4d;
  --ok-bg: #e5f4ec;
  --warn: #a35c00;
  --warn-bg: #fdf1df;
  --bad: #b3261e;
  --bad-bg: #fbe8e6;
  --info: #285a9c;
  --info-bg: #e7eef9;
  --nrti: #2f6fb6;
  --nnrti: #8a4fbf;
  --insti: #0f8b8d;
  --pi: #c0562b;
  --booster: #7a8494;
  --entry: #a2367a;
  --capsid: #6b8e23;
  --f-vc: #b3261e;
  --f-c: #e07a1f;
  --f-u: #e6b422;
  --f-r: #7fb36a;
  --f-vr: #4f8fbf;
  --f-nk: #9aa3b0;
  --radius: 12px;
  --shadow: 0 1px 2px rgba(16, 24, 40, .06), 0 4px 14px rgba(16, 24, 40, .06);
  color-scheme: light;
}
@media (prefers-color-scheme: dark) {
  :root:not([data-theme="light"]) {
    --bg: #0f1520; --surface: #172131; --surface-2: #1e2a3d; --ink: #e8edf5; --ink-2: #a8b4c6;
    --line: #2c3a50; --brand: #8fb8ee; --brand-2: #6aa0e6; --accent: #4cc1c3;
    --ok: #6fd19c; --ok-bg: #173527; --warn: #f2b45c; --warn-bg: #3a2a12; --bad: #ff8a80; --bad-bg: #3d1a18;
    --info: #9cc0f2; --info-bg: #1b2a44; color-scheme: dark;
  }
}
* { box-sizing: border-box; }
html { -webkit-text-size-adjust: 100%; }
body {
  margin: 0; background: var(--bg); color: var(--ink);
  font: 15px/1.55 -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, sans-serif;
}
a { color: var(--brand-2); }
h1, h2, h3, h4 { line-height: 1.25; margin: 0 0 .5em; }
h1 { font-size: 1.75rem; } h2 { font-size: 1.3rem; } h3 { font-size: 1.08rem; }
p { margin: 0 0 .8em; }
code, .mono { font-family: ui-monospace, SFMono-Regular, Menlo, monospace; font-size: .92em; }
.muted { color: var(--ink-2); }
.small { font-size: .86rem; }
.wrap { max-width: 1240px; margin: 0 auto; padding: 0 16px; }

/* header */
.topbar { background: var(--surface); border-bottom: 1px solid var(--line); position: sticky; top: 0; z-index: 20; }
.topbar .wrap { display: flex; align-items: center; gap: 18px; min-height: 58px; flex-wrap: wrap; }
.logo { display: flex; align-items: center; gap: 10px; text-decoration: none; color: var(--ink); font-weight: 700; }
.logo svg { width: 30px; height: 30px; }
.logo small { display: block; font-weight: 500; color: var(--ink-2); font-size: .72rem; letter-spacing: .02em; }
.nav { display: flex; gap: 4px; flex-wrap: wrap; margin-left: auto; }
.nav a { padding: 7px 11px; border-radius: 8px; text-decoration: none; color: var(--ink-2); font-weight: 500; }
.nav a:hover, .nav a.active { background: var(--surface-2); color: var(--ink); }
.nav a.cta { background: var(--brand); color: #fff; }
.nav a.cta:hover { background: var(--brand-2); }

main { padding: 24px 0 48px; }
.banner { background: var(--warn-bg); color: var(--warn); border: 1px solid color-mix(in srgb, var(--warn) 30%, transparent);
  border-radius: var(--radius); padding: 10px 14px; margin-bottom: 18px; font-size: .9rem; }
.banner.edu { background: var(--info-bg); color: var(--info); border-color: color-mix(in srgb, var(--info) 30%, transparent); }
footer { border-top: 1px solid var(--line); padding: 22px 0 40px; color: var(--ink-2); font-size: .85rem; }

/* cards & grid */
.card { background: var(--surface); border: 1px solid var(--line); border-radius: var(--radius); padding: 18px; box-shadow: var(--shadow); }
.card + .card { margin-top: 16px; }
.grid { display: grid; gap: 16px; }
.grid.two { grid-template-columns: repeat(auto-fit, minmax(320px, 1fr)); }
.grid.three { grid-template-columns: repeat(auto-fit, minmax(260px, 1fr)); }
.grid.four { grid-template-columns: repeat(auto-fit, minmax(210px, 1fr)); }
.stack > * + * { margin-top: 16px; }
.row { display: flex; gap: 12px; align-items: center; flex-wrap: wrap; }
.spacer { flex: 1; }

/* hero */
.hero { max-width: 900px; margin-bottom: 24px; }
.hero h1 { font-size: 2.1rem; letter-spacing: -.01em; }
.hero .lead { font-size: 1.08rem; color: var(--ink-2); }
.entry-cards { display: grid; grid-template-columns: 1fr 1fr; gap: 14px; margin-top: 16px; }
.entry { display: block; text-decoration: none; color: inherit; padding: 16px; border-radius: var(--radius);
  border: 1px solid var(--line); background: var(--surface); box-shadow: var(--shadow); transition: transform .12s; }
.entry:hover { transform: translateY(-2px); border-color: var(--brand-2); }
.entry b { display: block; font-size: 1.05rem; margin-bottom: 4px; color: var(--brand); }
@media (max-width: 860px) { .hero { grid-template-columns: 1fr; } .entry-cards { grid-template-columns: 1fr; } }

/* badges / chips */
.badge { display: inline-flex; align-items: center; gap: 5px; padding: 2px 9px; border-radius: 999px; font-size: .76rem;
  font-weight: 600; border: 1px solid transparent; white-space: nowrap; }
.b-preferred { background: var(--ok-bg); color: var(--ok); }
.b-alternative { background: var(--info-bg); color: var(--info); }
.b-other { background: var(--surface-2); color: var(--ink-2); }
.b-exclude, .b-contraindicated { background: var(--bad-bg); color: var(--bad); }
.b-caution, .b-avoid { background: var(--warn-bg); color: var(--warn); }
.b-adjust { background: #fff6d6; color: #7a5a00; }
.b-info, .b-monitor { background: var(--info-bg); color: var(--info); }
.b-benefit { background: var(--ok-bg); color: var(--ok); }
.cls { display: inline-block; padding: 1px 8px; border-radius: 6px; font-size: .74rem; font-weight: 700; color: #fff; }
.cls-NRTI { background: var(--nrti); } .cls-NNRTI { background: var(--nnrti); } .cls-INSTI { background: var(--insti); }
.cls-PI { background: var(--pi); } .cls-Booster { background: var(--booster); }
.cls-Entry { background: var(--entry); } .cls-Capsid { background: var(--capsid); }
.chip { display: inline-block; padding: 3px 9px; border-radius: 999px; background: var(--surface-2); margin: 2px; font-size: .82rem; }

/* forms */
form .section { margin-bottom: 18px; }
fieldset { border: 1px solid var(--line); border-radius: var(--radius); padding: 14px 16px 6px; margin: 0 0 16px; background: var(--surface); }
legend { font-weight: 700; padding: 0 6px; color: var(--brand); }
.fields { display: grid; grid-template-columns: repeat(auto-fit, minmax(200px, 1fr)); gap: 12px 16px; margin-bottom: 10px; }
label.f { display: flex; flex-direction: column; gap: 4px; font-weight: 600; font-size: .88rem; }
label.f span.hint { font-weight: 400; color: var(--ink-2); font-size: .8rem; }
input[type=text], input[type=number], select, textarea {
  font: inherit; padding: 8px 10px; border-radius: 8px; border: 1px solid var(--line); background: var(--surface); color: var(--ink); width: 100%; }
input:focus, select:focus, textarea:focus { outline: 2px solid color-mix(in srgb, var(--brand-2) 40%, transparent); border-color: var(--brand-2); }
.checks { display: grid; grid-template-columns: repeat(auto-fit, minmax(230px, 1fr)); gap: 4px 14px; margin-bottom: 10px; }
.checks label { display: flex; gap: 8px; align-items: flex-start; font-size: .9rem; padding: 3px 0; }
.checks input { margin-top: 3px; }
.group-title { font-size: .78rem; text-transform: uppercase; letter-spacing: .06em; color: var(--ink-2); margin: 8px 0 2px; font-weight: 700; }
.err { color: var(--bad); font-size: .82rem; font-weight: 500; }
.btn { display: inline-flex; align-items: center; gap: 8px; font: inherit; font-weight: 600; padding: 10px 18px; border-radius: 10px;
  border: 1px solid var(--brand); background: var(--brand); color: #fff; cursor: pointer; text-decoration: none; }
.btn:hover { background: var(--brand-2); }
.btn.ghost { background: transparent; color: var(--brand); }
.btn.ghost:hover { background: var(--surface-2); }
.form-actions { position: sticky; bottom: 0; background: color-mix(in srgb, var(--bg) 92%, transparent); backdrop-filter: blur(6px);
  padding: 12px 0; border-top: 1px solid var(--line); display: flex; gap: 10px; flex-wrap: wrap; }
.case-pills { display: flex; flex-wrap: wrap; gap: 8px; margin-bottom: 16px; }
.case-pills a { text-decoration: none; padding: 6px 12px; border-radius: 999px; border: 1px solid var(--line); background: var(--surface); font-size: .86rem; color: var(--ink); }
.case-pills a:hover { border-color: var(--brand-2); }
[hidden] { display: none !important; }

/* alerts */
.alert { border-radius: 10px; padding: 10px 14px; margin-bottom: 8px; border-left: 4px solid; font-size: .92rem; }
.alert.critical { background: var(--bad-bg); border-color: var(--bad); }
.alert.warning { background: var(--warn-bg); border-color: var(--warn); }
.alert.info { background: var(--info-bg); border-color: var(--info); }

/* report */
.report-layout { display: grid; grid-template-columns: minmax(0, 1fr) 320px; gap: 20px; align-items: start; }
@media (max-width: 1000px) { .report-layout { grid-template-columns: 1fr; } }
.summary dl { display: grid; grid-template-columns: auto 1fr; gap: 4px 12px; margin: 0; font-size: .88rem; }
.summary dt { color: var(--ink-2); }
.summary dd { margin: 0; font-weight: 600; }
.reg { border: 1px solid var(--line); border-radius: var(--radius); background: var(--surface); box-shadow: var(--shadow); margin-bottom: 16px; overflow: hidden; }
.reg.top { border: 2px solid var(--ok); }
.reg-head { display: flex; gap: 14px; align-items: center; padding: 14px 16px; flex-wrap: wrap; }
.rank { width: 36px; height: 36px; border-radius: 50%; display: grid; place-items: center; font-weight: 800; background: var(--surface-2); color: var(--ink-2); flex: none; }
.reg.top .rank { background: var(--ok); color: #fff; }
.reg-title { font-size: 1.15rem; font-weight: 700; }
.reg-sub { color: var(--ink-2); font-size: .88rem; }
.scorebar { width: 140px; height: 8px; border-radius: 99px; background: var(--surface-2); overflow: hidden; }
.scorebar i { display: block; height: 100%; background: linear-gradient(90deg, var(--accent), var(--ok)); }
.reg-body { padding: 0 16px 16px; display: grid; grid-template-columns: minmax(0, 1.2fr) minmax(0, 1fr); gap: 18px; }
@media (max-width: 760px) { .reg-body { grid-template-columns: 1fr; } }
.takes { display: flex; flex-wrap: wrap; gap: 10px; }
.take { background: var(--surface-2); border-radius: 10px; padding: 8px 10px; text-align: center; font-size: .78rem; min-width: 120px; }
.take a { color: var(--ink); text-decoration: none; font-weight: 600; }
.take .pill-svg { max-width: 220px; height: auto; display: block; margin: 0 auto 4px; color: var(--ink-2); }
.take img { max-width: 160px; max-height: 90px; display: block; margin: 0 auto 4px; border-radius: 6px; }
.findings { list-style: none; padding: 0; margin: 0; }
.findings li { display: grid; grid-template-columns: 22px 1fr; gap: 8px; padding: 6px 0; border-bottom: 1px dashed var(--line); font-size: .9rem; }
.findings li:last-child { border-bottom: 0; }
.ficon { width: 20px; height: 20px; border-radius: 50%; display: grid; place-items: center; font-size: .72rem; font-weight: 800; color: #fff; margin-top: 2px; }
.f-benefit .ficon { background: var(--ok); } .f-caution .ficon { background: var(--warn); }
.f-info .ficon { background: var(--info); } .f-exclude .ficon { background: var(--bad); }
.refs { display: inline-flex; gap: 4px; flex-wrap: wrap; margin-left: 4px; }
.ref { font-size: .72rem; padding: 0 6px; border-radius: 5px; background: var(--surface-2); color: var(--ink-2); text-decoration: none; border: 1px solid var(--line); white-space: nowrap; }
.ref:hover { color: var(--brand-2); border-color: var(--brand-2); }
.teach { margin-top: 4px; padding: 6px 10px; border-radius: 8px; background: color-mix(in srgb, var(--accent) 10%, transparent); font-size: .84rem; }
.teach::before { content: "Teaching point · "; font-weight: 700; color: var(--accent); }
.dose { background: #fff6d6; color: #5c4400; border-radius: 8px; padding: 8px 10px; font-size: .88rem; margin: 8px 0; }
@media (prefers-color-scheme: dark) { :root:not([data-theme="light"]) .dose, :root:not([data-theme="light"]) .b-adjust { background: #3a3212; color: #f5d97a; } }
details.excluded summary { cursor: pointer; font-weight: 600; }
.ex-row { padding: 8px 0; border-bottom: 1px solid var(--line); font-size: .9rem; }
table.data { border-collapse: collapse; width: 100%; font-size: .86rem; }
table.data th, table.data td { border-bottom: 1px solid var(--line); padding: 6px 8px; text-align: left; vertical-align: top; }
table.data th { background: var(--surface-2); font-weight: 700; }
.table-scroll { overflow-x: auto; }
.lvl { display: inline-block; min-width: 1.5em; text-align: center; border-radius: 6px; padding: 1px 8px; font-weight: 700; font-size: .8rem; }
.lvl-1 { background: var(--ok-bg); color: var(--ok); } .lvl-2 { background: #eef7e9; color: #4f7a2a; }
.lvl-3 { background: #fff6d6; color: #7a5a00; } .lvl-4 { background: var(--warn-bg); color: var(--warn); }
.lvl-5 { background: var(--bad-bg); color: var(--bad); }

/* adverse effects */
.freq-legend { display: flex; gap: 10px; flex-wrap: wrap; font-size: .8rem; margin: 6px 0 12px; }
.freq-legend span::before { content: ""; display: inline-block; width: 10px; height: 10px; border-radius: 3px; margin-right: 5px; background: var(--c); vertical-align: -1px; }
.ae-grid { display: grid; grid-template-columns: minmax(150px, 220px) 1fr; border: 1px solid var(--line); border-radius: 10px; overflow: hidden; }
.ae-grid > div { padding: 7px 10px; border-bottom: 1px solid var(--line); font-size: .86rem; }
.ae-soc { background: var(--surface-2); font-weight: 600; }
.ae-tag { display: inline-block; margin: 2px; padding: 2px 8px; border-radius: 999px; font-size: .8rem; color: #fff; background: var(--c); }
.ae-tag.light { color: #222; }
.freq-bars { display: grid; gap: 6px; }
.freq-bars .fb { display: grid; grid-template-columns: 100px 1fr 30px; gap: 8px; align-items: center; font-size: .82rem; }
.freq-bars .fb i { display: block; height: 10px; border-radius: 99px; background: var(--c); }

/* SmPC rendering */
.smpc-section { scroll-margin-top: 80px; }
.smpc-section h3 { display: flex; gap: 8px; align-items: baseline; }
.smpc-section h3 .num { color: var(--ink-2); font-weight: 600; font-size: .9rem; }
.smpc-body { font-size: .9rem; }
.smpc-body h4 { font-size: .92rem; margin: 12px 0 6px; color: var(--brand); }
.smpc-body table { border-collapse: collapse; width: 100%; font-size: .82rem; margin: 8px 0 12px; }
.smpc-body td { border: 1px solid var(--line); padding: 4px 6px; vertical-align: top; }
.smpc-body tr:first-child td { background: var(--surface-2); font-weight: 600; }
.toc { position: sticky; top: 74px; font-size: .86rem; }
.toc a { display: block; padding: 3px 0; text-decoration: none; color: var(--ink-2); }
.toc a:hover { color: var(--brand-2); }
.source { font-size: .8rem; color: var(--ink-2); border-top: 1px solid var(--line); margin-top: 10px; padding-top: 8px; }

/* tabs */
.tabs { display: flex; gap: 4px; border-bottom: 1px solid var(--line); margin-bottom: 16px; flex-wrap: wrap; }
.tabs button { font: inherit; border: 0; background: none; padding: 9px 13px; cursor: pointer; color: var(--ink-2); border-bottom: 3px solid transparent; font-weight: 600; }
.tabs button[aria-selected=true] { color: var(--brand); border-color: var(--brand); }
.tabpanel[hidden] { display: none; }

/* formulary */
.prod { display: flex; flex-direction: column; gap: 8px; }
.prod .pic { background: var(--surface-2); border-radius: 10px; padding: 10px; min-height: 110px; display: grid; place-items: center; color: var(--ink-2); }
.prod .pic .pill-svg { max-width: 100%; height: auto; display: block; margin: 4px auto; }
.prod .pic img { max-width: 100%; max-height: 140px; border-radius: 8px; }
.prod h3 { margin: 0; font-size: 1rem; }
.prod h3 a { color: var(--ink); text-decoration: none; }
.appearance { font-size: .8rem; color: var(--ink-2); font-style: italic; }

/* interaction matrix */
.matrix { border-collapse: separate; border-spacing: 2px; font-size: .78rem; }
.matrix th { font-weight: 600; padding: 4px; }
.matrix th.rot { height: 70px; vertical-align: bottom; }
.matrix th.rot div { writing-mode: vertical-rl; transform: rotate(180deg); }
.matrix td { width: 30px; height: 26px; border-radius: 5px; text-align: center; background: var(--surface-2); }
.matrix td.contraindicated { background: var(--bad); color: #fff; }
.matrix td.avoid { background: #e07a1f; color: #fff; }
.matrix td.adjust { background: #e6b422; color: #222; }
.matrix td.monitor { background: #79a7d8; color: #fff; }
.matrix td a { color: inherit; text-decoration: none; display: block; font-weight: 800; }
.matrix th.rowh { text-align: right; white-space: nowrap; }

/* timeline */
.timeline { width: 100%; min-width: 640px; height: auto; display: block; }
.art-table input, .art-table select { min-width: 120px; }

/* life-cycle diagram */
.lifecycle { width: 100%; height: auto; }
.lifecycle .step text { font-size: 12px; fill: var(--ink); }
.lifecycle .step rect.lbl { fill: var(--surface); stroke: var(--line); }
.lifecycle a:hover rect.tag { filter: brightness(1.15); }
.lifecycle .tagtext { font-size: 11px; font-weight: 700; fill: #fff; }

/* pharmacology quick facts */
.facts { display: grid; grid-template-columns: repeat(auto-fit, minmax(170px, 1fr)); gap: 10px; }
.fact { background: var(--surface-2); border-radius: 10px; padding: 10px 12px; }
.fact b { display: block; font-size: .74rem; text-transform: uppercase; letter-spacing: .05em; color: var(--ink-2); }
.fact span { font-size: .88rem; font-weight: 400; line-height: 1.45; }

@media print {
  .topbar, .form-actions, footer, .no-print { display: none !important; }
  body { background: #fff; } .card, .reg { box-shadow: none; }
}

/* quiz */
.quiz-options { display: grid; gap: 8px; margin-top: 12px; }
.quiz-option { display: flex; gap: 10px; align-items: flex-start; padding: 11px 14px; border: 1px solid var(--line);
  border-radius: 10px; text-decoration: none; color: var(--ink); background: var(--surface); }
.quiz-option:hover { border-color: var(--brand-2); }
.quiz-option .letter { font-weight: 800; color: var(--ink-2); flex: none; width: 1.2em; }
.quiz-option.correct { border-color: var(--ok); background: var(--ok-bg); }
.quiz-option.correct .letter { color: var(--ok); }
.quiz-option.wrong { border-color: var(--bad); background: var(--bad-bg); }
.quiz-option.wrong .letter { color: var(--bad); }
.quiz-mark { font-size: .8rem; }

/* pharmacokinetic curves */
.pk-curve { width: 100%; min-width: 560px; height: auto; display: block; }

/* printable outputs */
.letter, .leaflet { max-width: 760px; }
.letter h2, .leaflet h2 { margin-top: 0; }
.leaflet { font-size: 1.02rem; line-height: 1.6; }
.leaflet .takes { margin: 10px 0; }
@media print { .letter, .leaflet { border: 0; max-width: none; } }